Fat-blocking effect of nanofibers discovered -- ScienceDaily
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Fats-blocking impact of nanofibers found — ScienceDaily

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Tiny balls of nano-sized cellulose fibres added to meals diminished fats absorption by as much as half in laboratory and animal experiments, report scientists from Nanyang Technological College, Singapore (NTU Singapore) and Harvard College, United States.

This discovery might assist within the international battle in opposition to weight problems, as experiments carried out in a simulated gastrointestinal tract confirmed that nanocellulose fibres 100 occasions smaller than the width of a human hair might reduce fats absorption by as much as 48 per cent.

In animal experiments, rats fed with heavy cream containing nanocellulose absorbed 36 per cent much less fat than rats fed with heavy cream alone.

Affiliate Professor Joachim Bathroom and Affiliate Professor Ng Kee Woei from NTU’s Faculty of Supplies Science and Engineering, along with senior writer of the research, Affiliate Professor Philip Demokritou, from the Harvard T.H. Chan Faculty of Public Well being, found how nanocellulose can bind and entice fats molecules often called triglycerides.

Sometimes, digestive enzymes within the intestine will break down triglycerides into fatty acids, that are absorbed by the small intestines and transformed to fats by the human physique.

Nevertheless, when triglycerides are trapped in nanocellulose fibres — like how cotton balls take in oil — enzymes concerned in breaking down triglycerides for fats absorption are much less efficient, thus lowering the quantity of fatty acids that may be absorbed by the physique.

Printed within the scientific journal ACS Nano in June, this new technique of utilizing nanocellulose fibres as fats blockers has been granted a US provisional patent, collectively filed by Harvard and NTU.

Assoc Prof Ng Kee Woei, a biomedical engineer and supplies scientist, stated their discovering reinforces the traditional knowledge that consuming a excessive fibre eating regimen is sweet for well being.

“We’ve known for a long time that fibre in the diet has positive health benefits but what we have shown now, is that in animal experiments, fibres at the nanoscale are much more effective at reducing fat absorption than in its bulk form,” Assoc Prof Ng stated.

In experiments, 1 mg of nanocellulose was added to 100mg of heavy cream, a ratio of 1:100. Prof Ng thinks that if extra nanocellulose was added, it might have absorbed and trapped a bigger proportion of fats.

“Nanocellulose could be used as food additives or supplements that could help to mitigate fat absorption for certain groups of people, as the concentration can be adjusted for different applications. We look forward to establishing whether this will be safe and effective for people to take.”

Assoc Prof Joachim Bathroom, a scientist researching on nanomaterials stated cellulose is categorised by the US Meals & Drug Administration as a Typically Regarded As Secure (GRAS) materials as it’s present in all vegetation. Nanocellulose could be simply produced by grinding cellulose into extraordinarily fantastic powder.

“In our study, three types of nanocellulose were compared to commercially available fat-reducing options, and all of them performed much better in the amount of fats they trapped,” Assoc Prof Bathroom stated, though he highlighted that extra research are nonetheless wanted to find out why the three had higher efficiency.

Professor Philip Demokritou, Director of Harvard’s Middle for Nanotechnology and Nanotoxicology, stated the invention is like “having your cake and eating it too.”

To him, essentially the most thrilling facet is that fats absorption could be curbed merely by the usage of a nanoscale materials manufactured from naturally-obtained fibres derived from vegetation, engineered utilizing mechanical means with none chemical substances.

“I’m a believer that we should learn more from nature and use more nature-inspired and derived materials,” he stated. “There’s 4 billion years of free R&D there, and instead we always look toward chemicals.”

Giving an impartial remark from the medical perspective, Dr Terence Tan, Head, Superior Medication Oncology Centre in Singapore, stated: “Thus far, there’s ample proof to indicate that the absence of extra physique fats has a cancer-preventive impact, and lowers the danger of creating 13 several types of cancers together with widespread cancers corresponding to colorectal and post-menopausal breast cancers.

“Avoidance of weight gain in the form of excess body fat is therefore an important strategy in our fight against cancer. Excess fat in our food can easily tip the scale towards an excess of energy intake over energy expenditure, which in turn drives weight gain over time,” added Dr Tan, a most cancers specialist researching on nanotechnology in meals for more healthy residing and most cancers prevention.

“This new nature-derived nanocellulose technology has the potential of reducing digestion and absorption of excess fat from our food without compromising on quality and taste, and is very exciting and promising. I look forward to the further evaluation of this technology in animals and humans to validate the findings of this study.”

Shifting ahead, the NTU and Harvard scientists will proceed to probe the toxicological profile of nanocellulose to look at its security for consumption in massive quantities in additional animal trials.

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